Anti-CD59 / Complement Regulatory Protein / Protectin Antibody BHA10206747

Mfr.No.	966-MSM3X-P1ABX
Alternative Names	20kDa homologous restriction factor (HRF20) ; Complement regulatory protein ; Human leukocyte antigen MIC11 ; MAC-inhibitory protein (MACIP) ; Membrane attack complex inhibition factor (MACIF) ; Membrane inhibitor of reactive lysis ; MIRL ; MSK21 ; Protectin ; T cell activating protein
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	11p13
Clonality	Monoclonal
Description	Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival.
Host	Mouse
Immunogen	Recombinant full-length human CD59 protein
Positive Control	Daudi, CEM, K562, HPB.ALL, Jurkat, Raji, and human lymphocytes. Human lymph node and tonsil.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P13987
Uniprot	278573; 709466; 710641
Gene Id	966

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

Functional Studies (Order Ab without Azide); (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10206747	966-MSM3X-P1ABX	100µg	$393.20		Add to Cart

Anti-CD59 / Complement Regulatory Protein / Protectin Antibody BHA10206747

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