Anti-PAX8 Antibody BHA10205900

Mfr.No.	7849-MSM2-P1ABX
Alternative Names	Paired box 8 ; Paired box gene 8 ; paired box homeotic gene 8 ; Paired box protein Pax-8 ; Paired domain gene 8 ; PAX8
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	2q13
Clonality	Monoclonal
Description	Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
Host	Mouse
Immunogen	Recombinant human PAX8 fragment (aa60-261) (exact sequence is proprietary)
Positive Control	Raji cells. Renal Cell Carcinoma (RCC)
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q06710
Uniprot	469728
Gene Id	7849

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution