Anti-p53 Tumor Suppressor Protein Antibody BHA10205445

Mfr.No.	7157-MSM1X-P1ABX
Alternative Names	Antigen NY-CO-13 ; BCC7 ; Cellular Tumor Antigen p53 ; LFS1 ; TP53 ; Transformation Related Protein 53 (TRP53) ; Tumor Protein p53 ; Tumor Suppressor p53
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	17p13.1
Clonality	Monoclonal
Description	Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Host	Mouse
Immunogen	Recombinant human wild-type p53 protein
Isotype	IgG2a
Positive Control	MDA-MB-231 Cells. Breast or Colon carcinoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P04637
Uniprot	654481
Gene Id	7157

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
WB	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205445	7157-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-p53 Tumor Suppressor Protein Antibody BHA10205445

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