Anti-TSH-Receptor, B-Chain Antibody BHA10205560

Mfr.No.	7253-MSM5X-P1ABX
Alternative Names	CHNG1 ; hTSHRI ; LGR3 ; Thyroid-stimulating hormone receptor ; Thyrotropin receptor ; Thyrotropin receptor I ; TSHR
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic
Chromosome Location	14q31
Clonality	Monoclonal
Description	Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Host	Mouse
Immunogen	Recombinant human TSHR, B-Chain protein
Positive Control	293T Cells. Thyroid gland
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P16473
Uniprot	160411
Gene Id	7253

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205560	7253-MSM5X-P1ABX	100µg	$393.20		Add to Cart

Anti-TSH-Receptor, B-Chain Antibody BHA10205560

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