Anti-ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody BHA10204233

Mfr.No.	546-MSM1-P1ABX
Alternative Names	Alpha thalassemia/mental retardation syndrome X linked homolog ; ATP-dependent helicase ATRX ; ATR2 ; ATRX ; DNA-dependent ATPase and helicase ; MRXHF1 ; RAD54 ; RAD54L ; SFM1 ; SHS
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	Xq21.1
Clonality	Monoclonal
Description	ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 α to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with α thalassemia or ATRX syndrome
Host	Mouse
Immunogen	Recombinant human ATRX protein
Isotype	IgG1 Kappa
Positive Control	Raji, HeLa or A431 Cells. Pancreas, Adrenal, Ovary, Kidney, Prostate or Stomach.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P46100
Uniprot	533526; 653797
Gene Id	546

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA Buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
WB	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204233	546-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody BHA10204233

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