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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-CD95 / FAS / TNFRSF6 Antibody BHA10202370

SKU : BHA10202370

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NeoBiotechnologies, Inc.

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Mfr.No.	355-MSM1-P1ABX
Alternative Names	ALPS1A ; Apoptosis APO1 antigen 1 ; Apoptosis-mediating surface antigen FAS ; APT1 ; Delta Fas/APO1/CD95 ; Fas (TNF receptor superfamily ; member 6) ; Fas AMA ; Fas cell surface death receptor ; FAS1
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	10q24.1
Clonality	Monoclonal
Description	MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
Host	Mouse
Immunogen	Recombinant human CD95 protein
Isotype	IgG1 Kappa
Positive Control	MCF-7 cells; hepatocellular or bladder carcinoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P25445
Uniprot	244139
Gene Id	355

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

Functional Studies (Order Ab without Azide); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202370	355-MSM1-P1ABX	100µg	$393.20		Add to Cart

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