Anti-IgG4 (Ig Heavy Constant Gamma 4) Antibody BHA10202169

Mfr.No.	3503-MSM1-P1ABX
Alternative Names	Ig gamma 4 chain C region ; IGHG4 ; Immunoglobulin heavy constant gamma 4 (G4m marker)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	14q32.33
Clonality	Monoclonal
Description	The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
Host	Mouse
Immunogen	Recombinant human full-length IGHG4
Isotype	IgG1
Positive Control	Tonsil
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01861
Uniprot	510635
Gene Id	3503

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
WB	0.5-1μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

Have you used this product?

Rate it now..!!

SKU	Supplier No.	Size	Your price	Quantity
BHA10202169	3503-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-IgG4 (Ig Heavy Constant Gamma 4) Antibody BHA10202169

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Anti-IgG4 (Ig Heavy Constant Gamma 4) Antibody BHA10202169

Rate it now..!!