Anti-HLA-DP/-DQ/-DR (MHC II) Antibody BHA10201833

Mfr.No.	3115-MSM3-P1ABX
Alternative Names	HLA-DPB1 ; HLA-DQA1 ; HLA-DQB1 ; HLA-DRA ; HLA-DRB1 ; HLA-DRB3 ; HLA-DRB4 ; HLA-DRB5
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	6p21.3 (HLA-DP ; HLA-DR)
Clonality	monoclonal
Description	Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an  chain (36kDa) and a  chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six  and ten  chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Host	Mouse
Immunogen	Cells from human tonsil
Isotype	IgG1
Positive Control	Raji cells. Tonsil or lymph node
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P04440 (HLA-DP); P01908; P01909; P01920 (HLA-DQ); P01903 (HLA-DR)
Uniprot	347270 (HLA-DP); 550475 (HLA-DQ); 520048 (HLA-DR)
Gene Id	3115 (HLA-DP);3117 (HLA-DQ);3122 (HLA-DR)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); ,Optimal dilution for a specific application should be determined., IF ; IHC-F

Dilution

IF	0.5-1μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201833	3115-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-HLA-DP/-DQ/-DR (MHC II) Antibody BHA10201833

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