CELIAC1 ; DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE) ; HLA Class II DQ ; HLA class II histocompatibility antigen DQ ; HLA class II histocompatibility antigen DQ(1) alpha chain ; HLA class II histocompatibility antigen DQ(3) alpha chain ; HLA DQA1 ; HLA DQB ; HLA DQB1 ; IDDM1
Categories
Primary Antibodies
Cellular Localization
Cell Surface
Chromosome Location
6p21.3
Clonality
Monoclonal
Description
Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.ĀThis MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
Host
Mouse
Immunogen
T4-positive CTL clone HG-38
Isotype
IgG2a Kappa
Positive Control
Raji cells. Tonsil or lymph node
Reactivity
Human, Pig
Recombinant
FALSE
Regulatory
RUO
Swissprot
P01908; P01909; P01920
Uniprot
550475
Gene Id
3117;3118;3119
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
(No special pretreatment is required for IHC staining of formalin/paraffin tissues); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
0.5-1μg/ml
IHC-F
0.5-1μg/ml for 30 minutes at RT
Reviews of Anti-HLA-DQ (MHC II) Antibody BHA10201838