ADA-binding protein (ADABP) ; Adenosine deaminase complexing protein 2 (ADCP-2) ; Dipeptidyl peptidase 4 ; Dipeptidyl peptidase 4 soluble form ; Dipeptidyl peptidase IV membrane form ; Dipeptidyl peptidase IV soluble form ; Dipeptidyl peptidase, intestinal ; Dipeptidylpeptidase 4 ; Dipeptidylpeptidase IV ; DPP4
Categories
Primary Antibodies
Cellular Localization
Cell Surface
Chromosome Location
2q24.3
Clonality
Monoclonal
Description
Recognizes a glycoprotein of 110kDa, identified as CD26 (Workshop VI; Code: N-L039). It is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this MAb reacts with only glycosylated CD26, but not with the deglycosylated form. It does not prevent ADA binding to CD26.
Host
Mouse
Immunogen
Human T cell clone
Isotype
IgG2b Kappa
Positive Control
YT, HEP-G2 cells, and lymphocytes. Lymph nodes and tonsils.
Reactivity
Human, Rat
Recombinant
FALSE
Regulatory
RUO
Swissprot
P27487
Uniprot
368912
Gene Id
1803
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
0.5-1μg/ml
IHC-F
0.5-1.0μg/ml for 30 minutes at RT
Reviews of Anti-CD26 (DPP IV / ADA-Binding Protein) Antibody BHA10200741