Anti-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody BHA10200281

Mfr.No.	1080-MSM2-P1ABX
Alternative Names	ABC35 ; ATP Binding Cassette Superfamily C Member 7 (ABCC7) ; cAMP-dependent chloride channel ; CFTR ; CFTR/MRP ; Channel conductance-controlling ATPase ; Cystic Fibrosis Transmembrane Conductance Regulator ; MRP7 ; TNR CFTR
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic
Chromosome Location	7q31.2
Clonality	monoclonal
Description	Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Host	Mouse
Immunogen	Recombinant human full length CFTR
Isotype	IgG2a
Positive Control	MOLT-4 cells. Pancreas, Kidney or Placenta.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P13569 (Human)
Uniprot	489786, 621460, 661104 (Human)
Gene Id	1080 (Human)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., IF ; WB ; IHC-F

Dilution

IF	0.5-1μg/ml
WB	0.5-1μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200281	1080-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody BHA10200281

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