Anti-p21WAF1 (Tumor Suppressor Protein) Antibody BHA10200069

Mfr.No.	1026-MSM3-P1ABX
Alternative Names	Activating Fragment 1 ; CAP20 ; CDK-interacting protein 1 ; CDKI ; CDKN1 ; CDKN1A ; CIP1 ; Cyclin-dependent kinase inhibitor 1A (p21,Cip1) ; DNA Synthesis Inhibitor ; MDA6
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	6p21.31
Clonality	Monoclonal
Description	This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Host	Mouse
Immunogen	Recombinant full-length human CDKN1A protein
Isotype	IgG2a Kappa
Positive Control	HeLa Cells. Skin, colon, or breast carcinoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P38936
Uniprot	370771
Gene Id	1026

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
WB	1-2μg/ml
IHC-F	2-4μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200069	1026-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-p21WAF1 (Tumor Suppressor Protein) Antibody BHA10200069

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