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Home / Primary Antibodies / IHC Antibodies

Anti-ALYREF Antibody BHA11308826

SKU : BHA11308826

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Mfr.No.	BS9250
Alternative Names	ALY ; ALY/REF ; Aly/REF export factor ; BEF ; bZIP enhancing factor ; bZIP-enhancing factor BEF ; REF ; THO complex 4 ; THO complex subunit 4 ; Tho4 ; THOC 4 ; THOC-4 ; THOC4
Categories	Primary Antibodies
Chromosome Location	17q25.3
Clonality	polyclonal
Description	ALY (also designated THO complex subunit 4, THOC4, REF1, Refbp1 and BEF) is the mammalian homolog of the yeast mRNA export factor Yralp. A transcriptional coactivator, ALY belongs to the cytidylyltransferase family and is important in mRNA processing and export. During spliceosome assemby, it is recruited to messenger ribonucleoprotein (mRNP) complexes and becomes tightly associated with the spliced mRNP. Consistent with splicing-dependent recruitment, ALY co-localizes with splicing factors in the nucleus. It promotes transcriptional activation by promoting the dimerization of transcription factors containing basic leucine zipper domains. Although ubiquitously expressed, ALY specifically associates with the activation domains of LEF-1 and AML-1, both of which are protein components of the TCR α enhancer complex. Research indicates that ALY may mediate context-dependent transcriptional activation by facilitating the functional collaboration of multiple proteins in the TCR α enhancer complex.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 130-182 of Human ALY.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q86V81
Uniprot	Q86V81
Weight	27 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: ALY (K161) polyclonal antibody detects endogenous levels of ALY protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308826	BS9250	50µl	$190.44		Add to Cart
BHA11308826	BS9250	100µl	$294.44		Add to Cart

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