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Home / Primary Antibodies / IHC Antibodies

Anti-GUCY1A1 Antibody BHA11302117

SKU : BHA11302117

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Mfr.No.	BS3670
Alternative Names	Guanylate cyclase soluble subunit alpha-3 ; GCS-alpha-3 ; EC=4.6.1.2 ; GCS-alpha-1 ; Soluble guanylate cyclase large subunit ; GUC1A3 ; GUCSA3 ; GUCY1A1 ; GUCY1A3 ; GCSα1 ; GCS-α1
Categories	Primary Antibodies
Chromosome Location	4q32.1
Clonality	polyclonal
Description	Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 400-450 of Human GCS-α-1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q02108
Uniprot	Q02108
Weight	77 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: GCS-α-1 (D423) polyclonal antibody detects endogenous levels of GCS-α-1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302117	BS3670	50µl	$190.44		Add to Cart
BHA11302117	BS3670	100µl	$294.44		Add to Cart

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