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Home / Primary Antibodies / IHC Antibodies

Anti-CDKN1B Antibody BHA11302153

SKU : BHA11302153

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Mfr.No.	BS3714
Alternative Names	Cyclin-dependent kinase inhibitor 1B ; Cyclin-dependent kinase inhibitor ; p27 ; p27Kip1 ; CDKN1B ; KIP1
Categories	Primary Antibodies
Chromosome Location	12p13.1
Clonality	polyclonal
Description	Cell cycle progression is regulated by a series of cyclin-dependent kinases that consist of catalytic subunits, designated Cdks, and activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has been recently described that function as “mitotic inhibitors.” These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner, p16 and a more recently described p16 related inhibitor designated p15. A p21 related protein, p27, has been described as a negative regulator of G1 progression and has been speculated to function as a possible mediator of TGFβ-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and to a lesser extent with cyclin E and Cdk2.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 150-200 of Human p27 Kip1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P46527
Uniprot	P46527
Weight	27 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p27 Kip1 (A181) polyclonal antibody detects endogenous levels of p27 Kip1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302153	BS3714	50µl	$190.44		Add to Cart
BHA11302153	BS3714	100µl	$294.44		Add to Cart

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