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Home / Primary Antibodies / IHC Antibodies

Anti-NKX3-1 Antibody BHA11300616

SKU : BHA11300616

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Mfr.No.	BS1456
Alternative Names	Homeobox protein Nkx-3.1 ; Homeobox protein NK-3 homolog A ; NKX3-1 ; NKX3.1 ; NKX3A
Categories	Primary Antibodies
Chromosome Location	8p21.2
Clonality	polyclonal
Description	The homeobox gene Nkx-3.1 is the human homolog of Drosophila bagpipe, which, in conjunction with tinman, determines cell fate in the dorsal mesoderm. In mammalian species, Nkx-3.1 is predominantly expressed in prostate, and it regulates prostate development in response to sonic hedgehog (Shh) signaling by exerting growth-suppressive and differentiating effects on prostatic epithelium. Nkx-3.1 is also expressed at lower levels in other tissues, including the heart and gut, in a Shh independent manner, where it plays a role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate and minor salivary glands. Nkx-3.1 preferentially binds the TAAGTA sequence, which has not been reported for any other NK class homeoprotein. The human Nkx-3.1 gene is located on chromosome 8q21, which frequently undergoes a loss of heterozygosity, and although Nkx-3.1 is not a tumor suppressor gene, it may be a useful marker for benign and malignant prostate epithelium.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the N-terminual of Human Nkx-3.1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q99801
Uniprot	Q99801
Weight	38 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: NKX3.1 (L2) polyclonal antibody detects endogenous levels of NKX3.1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300616	BS1456	50µl	$190.44		Add to Cart
BHA11300616	BS1456	100µl	$294.44		Add to Cart

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