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Home / Primary Antibodies / IHC Antibodies

Anti-EGFR Antibody BHA11300283

SKU : BHA11300283

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Mfr.No.	BS1104
Alternative Names	Epidermal growth factor receptor ; Proto-oncogene c-ErbB-1 ; Receptor tyrosine-protein kinase erbB-1 ; ERBB ; ERBB1 ; HER1 ; EGFR
Categories	Primary Antibodies
Chromosome Location	7p11.2
Clonality	polyclonal
Description	The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 661-710 of Human EGFR.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P00533
Uniprot	P00533
Weight	175 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: EGFR (E687) polyclonal antibody detects endogenous levels of EGFR protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300283	BS1104	50µl	$190.44		Add to Cart
BHA11300283	BS1104	100µl	$294.44		Add to Cart

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