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Home / Primary Antibodies / IHC Antibodies

Anti-MAP2K1 Antibody BHA11300074

SKU : BHA11300074

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Mfr.No.	AP0402
Alternative Names	Dual specificity mitogen-activated protein kinase kinase 1 ; MAP kinase kinase 1 ; MAPKK 1 ; MKK1 ; ERK activator kinase 1 ; MAPK/ERK kinase 1 ; MEK 1 ; MAP2K1 ; MEK-1 ; PRKMK1
Categories	Primary Antibodies
Chromosome Location	15q22.31
Clonality	polyclonal
Description	MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 270-320 of Human MEK1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q02750
Uniprot	Q02750
Weight	43 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: MEK1 (P293) polyclonal antibody detects endogenous levels of MEK1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 99% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300074	AP0402	50µl	$190.44		Add to Cart
BHA11300074	AP0402	100µl	$294.44		Add to Cart

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