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Home / Proteins & Peptide

IGF-II, Human

SKU : BHP18500308

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iXCells Biotechnologies

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Mfr.No.	IX03147, IX03147-1, IX03147-10, IX03147-50
Description	Insulin-like Growth Factor II (IGF-II) is a single chain 7 kDa polypeptide, and shares a high degree of homology with insulin. During circulation in vivo, IGF-II is complexed to high affinity binding proteins, IGF Binding Proteins (IGFBP), which act as circulating reservoirs, transport IGF-II, and prolong the half life of IGF-II. The receptors of IGF-II (IGFRs) are transmembrane tyrosine receptors, and are heterotetrameric consisting of two alpha-subunits and two beta-subunits. IGFRs execute their role via intracellullar signaling molecules, such as IRS, shc, and PI3K. The functions of IGF-II include promoting cell survival, growth, proliferation, differentiation and motility. In particular, IGF-II promotes proliferation, inhibits death, and stimulates transformation in breast cancer cells.Recombinant human Insulin-like Growth Factor II (rhIGF-II) produced in E. coli is a single non-glycosylated polypeptide chain containing 68 amino acids. A fully biologically active molecule, rhIGF-II has a molecular mass of 7.6 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against 25mM Tris, pH8.0.
Molecular Weight	7.6 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P01344
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 20 ng/mL, measured by a cell proliferation assay using FDCP-1 cells, corresponding to a specific activity of 5x104 units/mg.

Synonyms	Insulin-like Growth Factor-II, Somatamedin A
Sequence	MAYRPSETLC GGELVDTLQF VCGDRGFYFS RPASRVSRRSRGIVEECCFR SCDLALLETY CATPAKSE

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant human Insulin-like Growth Factor II (rhIGF-II) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIGF-II remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500308-1	IX03147-1	1mg	$711		Add to Cart
BHP18500308-2	IX03147-10	10ug	$49		Add to Cart
BHP18500308-3	IX03147-50	50ug	$107		Add to Cart

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