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Home / Proteins & Peptide

IGF-I, Human

SKU : BHP18500219

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iXCells Biotechnologies

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Mfr.No.	IX03017, IX03017-1, IX03017-10, IX03017-50
Description	Insulin-like growth factor I (IGF-I) also known as Somatamedin C is a hormone similar in molecular structure to insulin. Human IGF-I has two isoforms (IGF-IA and IGF-IB) which is differentially expressed by various tissues. Mature human IGF-I respectively shares 94% and 96% aa sequence identity with mouse and rat IGF-I. Both IGF-I and IGF-II (another ligand of IGF) can signal through the IGF-I receptor (IGFIR), but IGF-II can alone bind the IGF-II receptor (IGFIIR/ Mannose-6-phosphate receptor). IGF-I plays an important role in childhood growth and continues to have anabolic effects in adults.?Recombinant human Insulin-like growth factor I (rhIGF-I) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhIGF-I has a molecular mass of 7.7 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	7.7 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P05019
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 5 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of 2.0x 105 units/mg.

Synonyms	IGF-IA; Somatamedin C
Sequence	GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQTGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Purity	95% by SDS-PAGE and HPLC analyses.
Storage	Lyophilized recombinant human Insulin-like growth factor I (rhIGF-I) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIGF-I should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500219-1	IX03017-1	1mg	$157		Add to Cart
BHP18500219-2	IX03017-10	10ug	$49		Add to Cart
BHP18500219-3	IX03017-50	50ug	$95		Add to Cart

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