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Home / Proteins & Peptide

IFN-gamma, Rat

SKU : BHP18500415

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iXCells Biotechnologies

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Mfr.No.	IX03274, IX03274-1, IX03274-10, IX03274-50
Description	Interferon gamma (IFN-gamma), also known as Type II interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells. The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and activates the IFN-gamma/JAK/STAT pathway. IFN-gamma signaling promotesbiological functions primarily related to antiviral and antibacterial defense, apoptosis, inflammation, and regulation of innate and acquired immune responses. While IFN-gammainduced inflammatory cascades summon a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.Recombinant Rat Interferon gamma (IFN-gamma) produced in E.coli is a single non-glycosylated polypeptide chain containing 134 amino acids. A fully biologically active molecule, rrIFN-gamma has a molecular mass of 15.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	15.5 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Rat
Accession Number	P01581
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.5 ng/ml, measured by cytotoxicity assay using WEHI-279 cells, corresponding to a specific activity of 2x106 units/mg.

Synonyms	Type II interferon, T cell interferon, MAF
Sequence	GTLIESLESL KNYFNSSSMD AMEGKSLLLD IWRNWQKDGNTKILESQIIS FYLRLFEVLK DNQAISNNIS VIESHLITNFFSNSKAKKDA FMSIAKFEVN NPQIQHKAVN ELIRVIHQLSPESSLRKRKR SRC

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Rat IFN-gamma remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, recombinant Rat IFN-gamma should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500415-1	IX03274-1	1mg	$623		Add to Cart
BHP18500415-2	IX03274-10	10ug	$49		Add to Cart
BHP18500415-3	IX03274-50	50ug	$70		Add to Cart

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