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Humanized Knockins

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hCXCR2

    hCXCR2

    • Strain : Embryo cryopres
    • KI/KO Gene : Cxcr2
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cxc
    • Description : The endogenous
  • hF12

    hF12

    • Strain : Repository Live
    • KI/KO Gene : F12
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-F12
    • Description : The endogenous
  • hF11

    hF11

    • Strain : Repository Live
    • KI/KO Gene : F11
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-F11
    • Description : The endogenous
  • hACE2

    hACE2

    • Strain : Repository Live
    • KI/KO Gene : ACE2
    • Research Application : Corona Virus R
    • Nomenclature : C57BL/6Smoc-Ace
    • Description : A human ACE2-fl
  • h4-1BB(2)/hPD-1

    h4-1BB(2)/hPD-1

    • Strain : Repository Live
    • KI/KO Gene : Pdcd1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : h4-1BB(2)(NM-HU
  • h4-1BB(2)/hCD3E(2)

    h4-1BB(2)/hCD3E(2)

    • Strain : Repository Live
    • KI/KO Gene : CD3E
    • Research Application : Immunotherapy E
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : h4-1BB(2)(NM-HU
  • hANGPT2

    hANGPT2

    • Strain : Developing
    • KI/KO Gene : Angpt2
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Ang
    • Description : The endogenous
  • hB7H4

    hB7H4

    • Strain : Embryo cryopres
    • KI/KO Gene : Vtcn1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Vtc
    • Description : This VTCN1 huma
  • hB7H3

    hB7H3

    • Strain : Embryo cryopres
    • KI/KO Gene : CD276
    • Research Application : Cancer Research
    • Nomenclature : C57BL/6Smoc-Cd2
    • Description : The endogenous
  • hB2M-HLA A2.1(NMG,2)

    hB2M-HLA A2.1(NMG,2)

    • Strain : Repository Live
    • KI/KO Gene : B2m
    • Research Application : Humanized Drug
    • Nomenclature : NOD-PrkdcscidIl
    • Description : The endogenous
  • hC5AR1

    hC5AR1

    • Strain : Repository Live
    • KI/KO Gene : C5AR1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-C5a
    • Description : The endogenous
  • hCCL5

    hCCL5

    • Strain : Sperm cryoprese
    • KI/KO Gene : Ccl5
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-CCL
    • Description : The endogenous
  • hCCL4

    hCCL4

    • Strain : Embryo cryopres
    • KI/KO Gene : Ccl4
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Ccl
    • Description : The endogenous
  • hCB1

    hCB1

    • Strain : Repository Live
    • KI/KO Gene : Cnr1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cnr
    • Description : The endogenous
  • hC5AR1/C5AR2

    hC5AR1/C5AR2

    • Strain : Sperm cryoprese
    • KI/KO Gene : C5AR1
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-C5a
    • Description : The endogenous
  • hIL21R

    hIL21R

    • Strain : Repository Live
    • KI/KO Gene : IL21R
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il2
    • Description : The endogenous
  • hIL21

    hIL21

    • Strain : Repository Live
    • KI/KO Gene : IL21
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il2
    • Description : The endogenous
  • hIL2RA/hIL2RG

    hIL2RA/hIL2RG

    • Strain : Embryo cryopres
    • KI/KO Gene : IL2RA
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il2
    • Description : hIL2RG(NM-HU-20
  • hIL23A

    hIL23A

    • Strain : Repository Live
    • KI/KO Gene : Il23a
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il2
    • Description : The endogenous
  • hIL21R/hIL2RG

    hIL21R/hIL2RG

    • Strain : Embryo cryopres
    • KI/KO Gene : IL21R
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il2
    • Description : hIL21R(NM-HU-21
  • hIL31

    hIL31

    • Strain : Repository Live
    • KI/KO Gene : Il31
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il3
    • Description : The endogenous
  • hIL3/hCSF2/hCSF1

    hIL3/hCSF2/hCSF1

    • Strain : Embryo cryopres
    • KI/KO Gene : CSF1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il3
    • Description : hIL3(NM-HU-1900
  • hIL3

    hIL3

    • Strain : Embryo cryopres
    • KI/KO Gene : IL3
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il3
    • Description : The endogenous
  • hIL5-Tg(NMG,2)

    hIL5-Tg(NMG,2)

    • Strain : Sperm cryoprese
    • KI/KO Gene : Gt(ROSA)26Sor
    • Research Application : Humanized Drug
    • Nomenclature : NOD-PrkdcscidIl
    • Description : These transgeni
  • hIL4RA

    hIL4RA

    • Strain : Embryo cryopres
    • KI/KO Gene : Il4ra
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il4
    • Description : The endogenous