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Humanized Knockins

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hIL2/hIL2RA(BALB/c)

    hIL2/hIL2RA(BALB/c)

    • Strain : Repository Live
    • KI/KO Gene : IL2
    • Research Application : Humanized Drug
    • Nomenclature : BALB/cAnSmoc-Il
    • Description : The endogenous
  • hIL5/hIL5R(2)

    hIL5/hIL5R(2)

    • Strain : Repository Live
    • KI/KO Gene : IL5
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il5
    • Description : The endogenous
  • hIL4-Tg(NMG)(2)

    hIL4-Tg(NMG)(2)

    • Strain : Developing
    • KI/KO Gene : Gt(ROSA)26Sor
    • Research Application : Humanized Drug
    • Nomenclature : NOD-PrkdcscidIl
    • Description : These transgeni
  • hITGB1

    hITGB1

    • Strain : Repository Live
    • KI/KO Gene : Itgb1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Itg
    • Description : The endogenous
  • hIL9

    hIL9

    • Strain : Repository Live
    • KI/KO Gene : Il9
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Il9
    • Description : The endogenous
  • hLILRA4

    hLILRA4

    • Strain : Sperm cryoprese
    • KI/KO Gene : Lair1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Lai
    • Description : The endogenous
  • hLGALS9

    hLGALS9

    • Strain : Repository Live
    • KI/KO Gene : Lgals9
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Lga
    • Description : The endogenous
  • hMELTF

    hMELTF

    • Strain : Embryo cryopres
    • KI/KO Gene : Klrg1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Mel
    • Description : The endogenous
  • hMASP2

    hMASP2

    • Strain : Repository Live
    • KI/KO Gene : Masp2
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Mas
    • Description : The endogenous
  • hNECTIN4

    hNECTIN4

    • Strain : Repository Live
    • KI/KO Gene : Nectin4
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Nec
    • Description : The endogenous
  • hOX40L(2)

    hOX40L(2)

    • Strain : Embryo cryopres
    • KI/KO Gene : Tnfsf4
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : The endogenous
  • hOCLN

    hOCLN

    • Strain : Embryo cryopres
    • KI/KO Gene : Ocln
    • Research Application : Hcv Infection R
    • Nomenclature : C57BL/6Smoc-Ocl
    • Description : The endogenous
  • hNRP1

    hNRP1

    • Strain : Embryo cryopres
    • KI/KO Gene : Nrp1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Nrp
    • Description : The endogenous
  • CAG-hACE2-IRES-Luc-Tg

    CAG-hACE2-IRES-Luc-Tg

    • Strain : Repository Live
    • Research Application : Corona Virus R
    • Nomenclature : C57BL/6Smoc-Tgt
    • Description : The transgene i
    • Synonyms : ACEH
  • h4-1BB(2)/hOX40

    h4-1BB(2)/hOX40

    • Strain : Embryo cryopres
    • KI/KO Gene : 4-1BB
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : hTNFRSF9(NM-HU-
  • hAppNL-F

    hAppNL-F

    • Strain : Embryo cryopres
    • KI/KO Gene : App
    • Research Application : Alzheimer'S Dis
    • Nomenclature : C57BL/6Smoc-App
    • Description : The endogenous
  • hAGT

    hAGT

    • Strain : Repository Live
    • KI/KO Gene : Agt
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Agt
    • Description : The endogenous
  • hB7H3/hPD-1

    hB7H3/hPD-1

    • Strain : Embryo cryopres
    • KI/KO Gene : CD276
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cd2
    • Description : hB7-H3(NM-HU-00
  • hB7H3/hCD28

    hB7H3/hCD28

    • Strain : Embryo cryopres
    • KI/KO Gene : CD276
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cd2
    • Description : hB7-H3(NM-HU-00
  • hB2M-HLA A2.1(NMG)

    hB2M-HLA A2.1(NMG)

    • Strain : Developing
    • KI/KO Gene : H2-D1
    • Research Application : Humanized Drug
    • Nomenclature : NOD-PrkdcscidIl
    • Description : The endogenous
  • hC1S

    hC1S

    • Strain : Repository Live
    • KI/KO Gene : C1s1
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-C1s
    • Description : The endogenous
  • hCCR4(2)

    hCCR4(2)

    • Strain : Embryo cryopres
    • KI/KO Gene : Il12rb1
    • Nomenclature : C57BL/6Smoc-Ccr
    • Research Application : Humanized Drug
    • Description : The endogenous
  • hCALCRL

    hCALCRL

    • Strain : Repository Live
    • KI/KO Gene : Calcrl
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cal
    • Description : The endogenous
  • hCD20(2)

    hCD20(2)

    • Strain : Repository Live
    • KI/KO Gene : Ms4a1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Ms4
    • Description : Extracellular a
  • hCD33

    hCD33

    • Strain : Embryo cryopres
    • KI/KO Gene : Cd33
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cd3
    • Description : The endogenous