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Humanized Knockins
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Humanized Knockins
The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.
775 Result Found
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hLAG3/hCTLA-4
- Description : This LAG3 and C
- Nomenclature : B6.129S-Lag3tm1
- Strain : Embryo cryopres
- KI/KO Gene : CTLA4
- Synonyms : Cd152; Ly-56;
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hLAG3(BALB/c)
- Description : The endogenous
- Nomenclature : BALB/cAnSmoc-La
- Strain : Developing
- KI/KO Gene : Lag3
- Synonyms : Ly66, CD223, LA
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hOX40/hOX40L(2)
- Description : hTNFSF4(NM-HU-2
- Nomenclature : C57BL/6Smoc-Tnf
- Strain : Embryo cryopres
- KI/KO Gene : Ncr1
- Synonyms : Ath1, gp34, Ath
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hPD-1/hCTLA-4
- Description : hPD-1(NM-HU-000
- Nomenclature : C57BL/6Smoc-Pdc
- Strain : Embryo cryopres
- KI/KO Gene : CTLA4
- Synonyms : Cd152; Ly-56;
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hPD-1/hCD40
- Description : hPD-1(NM-HU-000
- Nomenclature : C57BL/6Smoc-Pdc
- Strain : Embryo cryopres
- KI/KO Gene : CD40
- Synonyms : IGM; p50; Bp5
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hPD-1/hPD-L1(2)/hCCR8
- Description : hPD-1(NM-HU-000
- Nomenclature : C57BL/6Smoc-Pdc
- Strain : Developing
- KI/KO Gene : CD27
- Synonyms : Cd27; S152; T
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hPD-1/hOX40
- Description : hPD-1(NM-HU-000
- Nomenclature : C57BL/6Smoc-Pdc
- Strain : Embryo cryopres
- KI/KO Gene : Tnfrsf4
- Synonyms : Ox40; ACT35;
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hENTPD1(3)
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-En
- Strain : Embryo cryopres
- KI/KO Gene : Entpd1
- Synonyms : Cd39, AA408691,
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hCD40/hCD40LG(BALB/c)
- Description : Model Descripti
- Nomenclature : BALB/cAnSmoc-Cd
- Strain : Developing
- Target : Tumor Targets
- KI/KO Gene : CD40
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hCD47/hSIRPA(2)/hCD38(2)
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-Si
- Strain : Developing
- Target : Tumor Targets
- KI/KO Gene : SIRPA
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hCEACAM6-Tg
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-Tg
- Strain : Developing
- Target : Tumor Targets
- KI/KO Gene : Tgtn(hCEACAM6)1
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hADORA2A(BALB/c)
- Description : Model Descripti
- Nomenclature : BALB/cAnSmoc-Ad
- Strain : Developing
- Target : Tumor Targets
- KI/KO Gene : Adora2a
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hIL2RA/hTNFRSF1B
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-Il
- Strain : Developing
- Target : Metabolic Targe
- KI/KO Gene : TNFRSF1B
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hIL36A/hIL36B/hIL36G
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-Il
- Strain : Developing
- Target : Metabolic Targe
- KI/KO Gene : Il1f6
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hPVRL2/hPVRIG
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-Ne
- Strain : Developing
- Target : Metabolic Targe
- KI/KO Gene : Pvrig
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hSIRPA/hCD47(BALB/c)
- Description : Model Descripti
- Nomenclature : BALB/cAnSmoc-Si
- Strain : Repository Live
- Target : Immune Checkpoi
- KI/KO Gene : SIRPA
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hSIRPA(2)/hCD47/hPD-1/hPD-L1
- Description : Model Descripti
- Nomenclature : C57BL/6JSmoc-Si
- Strain : Repository Live
- Target : Immune Checkpoi
- KI/KO Gene : Pdcd1
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