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Humanized Knockins

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hTHPO

    hTHPO

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Th
    • Strain : Embryo cryopres
    • Target : Cytokines
    • KI/KO Gene : Thpo
  • hTNFSF14

    hTNFSF14

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tn
    • Strain : Repository Live
    • Target : Cytokines
    • KI/KO Gene : Tnfsf14
  • hTSLP/hIL17RA

    hTSLP/hIL17RA

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Ts
    • Strain : Embryo cryopres
    • Target : Cytokines
    • KI/KO Gene : TSLP
  • R26-LSL-hIL15-Flag-IRES-EGFP

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Gt
    • Strain : Repository Live
    • Target : Cytokines
    • KI/KO Gene : Gt(ROSA)26Sor
  • hTGFB1

    hTGFB1

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Developing
    • Target : Cytokines
    • KI/KO Gene : Tgfb1
  • hTNFSF13B

    hTNFSF13B

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tn
    • Strain : Developing
    • Target : Cytokines
    • KI/KO Gene : Tnfsf13b
  • hTNFa-Tg

    hTNFa-Tg

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Sperm cryoprese
    • Target : Cytokines
    • KI/KO Gene : TNF
  • hTNFSF11/hSIGLEC15

    hTNFSF11/hSIGLEC15

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tn
    • Strain : Developing
    • Target : Cytokines
    • KI/KO Gene : TNFSF11
  • hTSLP

    hTSLP

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Ts
    • Strain : Embryo cryopres
    • Target : Cytokines
    • KI/KO Gene : Tslp