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Human IFN-beta protein

SKU : BHP13700062

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100183
Description	Human IFN-beta protein, expressed in CHO Stable Cells
Alternative Names	IFB; IFF; IFN-beta; IFNB; Interferon beta; Interferon beta; IFNB1
Background	Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or cause autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of a chronic progressive CNS inflammation.
Immunogen Region	PRP100183
Tag	IFN-beta
Formulation	Lyophilized from sterile 10mM NaAC, 40mM Arg, 0.12mg/ml Met, 146mg/ml Sucrose, 0.1% PF-68, pH 4.5
Molecular Weight	20 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IFN-beta protein in 30mM Acetic acid not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	P01574
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Bioactivity	Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitisvirus (VSV).The ED50 for this effect is 2-20 pg/mL.
Protein Length	The recombinant human IFN-beta consists of 166 amino acids and predicts a molecular mass of 20 KDa. It migrates as an approximately 20-23 KDa band in SDS-PAGE under reducing conditions.
Others	The Endotoxin level is less than 1.0 EU per ug of the protein as determined by the LAL method Preparation Method: CHO Stable Cells

Sequence	Amino acid sequence derived from human IFN-beta (P01574) (Met1-Asn187) was expressed.

Purity	> 95 % as determined by SDS-PAGE
Storage	Lyophilized Human IFN-beta proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.53% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700062	PRP100183	20 ug	$349		Add to Cart
BHP13700062	PRP100183	100 ug	$1439		Add to Cart
BHP13700062	PRP100183	1 mg	$8069		Add to Cart

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