Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
This HIF1A antibody was produced from mouse immunized with HIF1A recombinant protein.
Isotype
Mouse IgM, k
Species Reactivity
Human
Note
Titration of the HIF1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
Q16665
Format
Ascites
Purity
Ascites
Storage
Aliquot the HIF1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.