Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
This HIF1A antibody was produced from mouse immunized with HIF1A recombinant protein.
Isotype
IgM,k
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Uniprot
Q16665
Clone No
288CT11.7.1
Format
Ascites
Purification
Ascites
Storage
Aliquot the HIF1A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.