The hemoglobin molecule is a tetramer consisting of two alpha-and two beta-globin-like chains. HBE1(hemoglobin epsilon chain) is a beta-type chain of hemoglobin predominantly expressed during the embryonic stage(21321359). The HBE1 has been regarded as the best marker for fetal nucleated red blood cells(NRBCs) . This antibody can be used to label and isolate fetal cells from mateal blood and may be useful in prenatal diagnosis(15906407).