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Home / Primary Antibodies / Monoclonal Antibodies

GIT1 Antibody, Clone S39B-8 - SMC-413

BHA11903754
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+1 866.986.9598
Email
[email protected]
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Swissprot Q9Z272.1
Accession Number NP_114002.1
Gene Id 83709
Target GIT1
Clone No S39B-8
Research Area Cell Markers, Neuron Markers, Cell Signaling, Scaffold Proteins, Post-translational Modifications, Phosphorylation, Neuroscience, Cytoplasmic Markers
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF, Rac and cdc42), kinases (such as PAK and MEK), the Rho family GEF PIX, and the focal adhesion protein paxillin (reviewed in 1). GIT-1 is localized to focal adhesions, cytoplasmic complexes and membrane protrusions, and regulates cell protrusion formation and cell migration (2). GIT-1 has also been implicated in neuronal functions including synapse formation (3) and the pathology of Huntington disease (4). Huntington disease is a genetic neurodegenerative condition involving a mutation in the huntington gene. The huntington gene product (htt) is ubiquitinated and degraded in human Huntington disease brains (5). Htt interacts directly with GIT-1 causing enhanced htt proteolysis, indicating that GIT-1 distribution and function may contribute to Huntington disease pathology (4).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~90kDa. Does not cross-react with GIT2.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IP, WB, ICC/IF
Description WB ; ICC ; IF ; IP
Dilution WB (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Hoefen R.J. and Berk B.C. (2006) J. Cell Sci. 119: 146 1475.

2. Manabe R., et al. (2002) J. Cell Sci. 115: 1497-1510.

3. Zhang H., et al. (2003) J. Cell Biol. 161: 131-142.

4. Goehler H., et al. (2004) Mol. Cell 15: 853-865.

5. Mende-Mueller L.M., et al. (2001) J. Neurosci. 21: 1830-1837.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11903754-1 SMC-413D Unconjugated 100 ug $330
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BHA11903754-2 SMC-413D-A390 ATTO 390 100 ug $384
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BHA11903754-3 SMC-413D-A488 ATTO 488 100 ug $383
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BHA11903754-4 SMC-413D-A594 ATTO 594 100 ug $383
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BHA11903754-5 SMC-413D-ALP Alkaline Phosphatase 100 ug $376
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BHA11903754-6 SMC-413D-APC APC 100 ug $382
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BHA11903754-7 SMC-413D-BI Biotin 100 ug $378
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BHA11903754-8 SMC-413D-FITC FITC 100 ug $374
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BHA11903754-9 SMC-413D-HRP HRP 100 ug $370
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BHA11903754-10 SMC-413D-PCP PerCP 100 ug $382
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BHA11903754-11 SMC-413D-RPE RPE 100 ug $380
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BHA11903754-12 SMC-413S Unconjugated 12 ug $44
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