SUMO1 Antibody

Mfr.No.	CSB-PA022948KA01HU
Alternative Names	SUMO1;DAP1;GMP1;OFC10;PIC1;SENP2;SMT3;SMT3C;SMT3H3; UBL1
Categories	Primary Antibodies
Description	Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family. The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein. Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regulates degradation of its target. In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease.
Hgnc	17927
Host	Rabbit
Immunogen	A synthetic peptide of Human SUMO-1
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Non-syndromic orofacial cleft 10 (OFC10)
Isotype	IgG
Mgi	2445054
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family. The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein. Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regulates degradation of its target. In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus membrane, Nucleus speckle, Cytoplasm, Nucleus, PML body, Cell membrane, Nucleus

Rgd	1310275
Target Details	This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Uniprot	P63165
Database Links	HGNC:12502 OMIM:601912 KEGG:hsa:7341 STRING:9606.ENSP00000376076 UniGene:Hs.81424
Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1
Protein Families	Ubiquitin family, SUMO subfamily

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC, ICC, IP, FC

Description

ELISA ; WB ; IHC ; ICC ; IP ; FC, FACS ; ELISA ; ICC ; IHC ; IP ; WB

Dilution

WB	1:500-1:2000
IHC	1:20-1:200
ICC	1:50-1:200
IP	1:20-1:50
FC	1:20-1:50

Tested Application

ELISA,WB,IHC,ICC,IP,FC;WB:1:500-1:2000,IHC:1:20-1:200,ICC:1:50-1:200,IP:1:20-1:50,FC:1:20-1:50

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Flow Cytometry (FC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557334	CSB-PA022948KA01HU	100μl	$387.33		Add to Cart

SUMO1 Antibody

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