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Home / Primary Antibodies / Recombinant Antibodies

Phospho-Histone H3.3 (T3) Antibody

SKU : BHA10560687

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA010109A03phHU
Alternative Names	Histone H3.3, H3F3A, H3.3A, H3F3, PP781, AND, H3F3B, H3.3B
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Description	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Host	Rabbit
Immunogen	A synthesized peptide
Involvement In Disease	Glioma (GLM)
Isotype	IgG
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus, Chromosome

Uniprot	P84243
Gene Name	H3F3A
Database Links	HGNC:4764 OMIM:137800 KEGG:hsa:3020 STRING:9606.ENSP00000355778 UniGene:Hs.180877
Function	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Protein Families	Histone H3 family
Research Area	Epigenetics and Nuclear Signaling

Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Liquid
Format	Liquid
Purification	Affinity-chromatography
Purity	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Applications

ELISA, WB, ICC, FC

Description

ELISA ; WB ; ICC ; FC, FACS ; ELISA ; ICC ; WB

Dilution

WB	1:500-1:5000
ICC	1:50-1:500

Tested Application

ELISA, WB, ICC, FC; Recommended dilution: WB:1:500-1:5000, ICC:1:50-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Flow Cytometry (FC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560687	CSB-RA010109A03phHU	100ul	$350		Add to Cart
BHA10560687	CSB-RA010109A03phHU	50ul	$210		Add to Cart

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