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Home / Primary Antibodies / IHC Antibodies

Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody

SKU : BHA12103493

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Mfr.No.	BT-AP01890
Alternative Names	CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	ERO1L, also named as ERO1-alpha, is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. It is required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. This antibody has no cross reaction to ERO1L.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Host	Rabbit(Rb)
Immunogen	The antiserum was produced against synthesized peptide derived from human CASP3. AA range:126-175
Isotype	IgG
Reactivity	Human
Regulatory	RUO

Weight	54 kDa

Concentration	1 mg/ml
Description	Brand/Origin: BT/Shanghai
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Store at 4°C for a month, for one year store at -20°C. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-20°C. Avoid repeated freeze/thaw cycles.
Storage Stability	-20°C/1 year

Applications	ELISA, IHC-P
Description	FACS ; WB ; IP ; IHC ; ELISA
Dilution	Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12103493	BT-AP01890	100µl	$226		Add to Cart
BHA12103493	BT-AP01890	50µl	$110.45		Add to Cart
BHA12103493	BT-AP01890	20µl	$69.16		Add to Cart

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