The 4AM15 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor. It is a member of the lg superfamily,primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC classII and associating with the protein tyrosine kinase, lck. 1. Nakamura.T. 1992.Personal communication.2. Bendelac.A.1995.Mouse NK1 T Cells.Curr.Opin.Immunol.7:367-3743. Shevach,E.M.2000.Regulatory T cells in autoimmunity.Annu.Rev.Immunol.
Host
Rat
Isotype
IgG2b
Raised In
Rat
Reactivity
Mouse
Regulatory
RUO
Relevance
The 4AM15 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor. It is a member of the lg superfamily,primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC classII and associating with the protein tyrosine kinase, lck.
1. Nakamura.T. 1992.Personal communication.
2. Bendelac.A.1995.Mouse NK1 T Cells.Curr.Opin.Immunol.7:367-374
3. Shevach,E.M.2000.Regulatory T cells in autoimmunity.Annu.Rev.Immunol.