CD4 APC-iFluor700 SK3 IgG1,k (RUO)

Mfr.No.	1120174, 1120175, 1120176
Antigen	CD4
Clonality	Monoclonal
Conjugate	APC-iFluor^TM 700
Description	The clone SK3, a mouse monoclonal antibody selectively binds with a 55-59kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD4 contains four extracellular Ig-like domains (D1-D4). The epitope for SK3 is located within the D3 domain of the protein, which has a structure resembling an Ig variable domain. Expression of CD4 is observed in subsets of T lymphocytes, monocytes, macrophages, and dendritic cells. Through interaction of MHC-II, CD4 facilitates cell-cell interaction, thymic differentiation, and activation of downstream signaling cascades. HIV infection of T-cells is instigated through binding of HIV to CD4. Binding of SK3 antibody blocks HIV infection through CD4 and also blocks the mixed lymphocyte reaction (MLR).
Host	Mouse
Immunogen Region	Human peripheral blood T cells
Isotype	IgG1,k
Reactivity	Cynomolgus monkey, Human, Rhesus

Product Manual	Datasheet MSDS

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Combination SKU	Supplier No.	Size	Your price
BHA19900419-1	1120174	25 test	$125	Add to Cart
BHA19900419-2	1120175	100 test	$265	Add to Cart
BHA19900419-3	1120176	200 test	$445	Add to Cart