Clgi ; Collagenase inhibitor ; Collagenase inhibitor, Human ; EPA ; EPO ; Erythroid Potentiating Activity ; Erythroid-potentiating activity ; Fibroblast collagenase inhibitor ; FLJ90373 ; HCI ; Human Collagenase Inhibitor ; Metalloproteinase inhibitor 1 ; Metalloproteinase inhibitor 1 precursor ; TIMP 1 ; TIMP ; TIMP metallopeptidase inhibitor 1 ; TIMP-1 ; TIMP1 protein ; Tissue Inhibitor of Metalloproteinase 1 ; Tissue inhibitor of metalloproteinases 1
Categories
Primary Antibodies
Cellular Localization
Secreted, Cytoplasmic
Chromosome Location
Xp11.23
Clonality
Monoclonal
Description
TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.
Host
Mouse
Immunogen
Recombinant full-length human TIMP1 protein
Isotype
IgG1
Positive Control
293 cell extract, or rat brain lysate. Human colon carcinoma.
Reactivity
Human
Recombinant
TRUE
Regulatory
RUO
Species
Homo Sapiens (Human)
Swissprot
P01033
Gene Id
7076
Clone No
1710, rTIMP1
Symbol
TIMP1
Weight
23kDa
Buffer
200μg/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Applications
FACS, IF, WB, IHC-F
Description
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F
Dilution
Flow Cytometry
0.5-1μg/million cells
Immunofluorescence
0.5-1μg/ml
Western Blotting
0.5-1.0μg/ml
Immunohistology (Formalin-fixed)
0.5-1.0μg/ml for 30 minutes at RT
Reviews of Anti-undefined Antibody rTIMP1,1710 Unconjugated BHA10208298