82 kDa matrix metalloproteinase-9 ; 92 kDa gelatinase ; 92 kDa type IV collagenase ; CLG 4B ; CLG4B ; Collagenase Type 4 beta ; Collagenase type IV 92 KD ; EC 3.4.24.35 ; Gelatinase 92 KD ; Gelatinase B ; Gelatinase beta ; GelatinaseB ; GELB ; Macrophage gelatinase ; MANDP2 ; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) ; Matrix Metalloproteinase 9 ; MMP 9 ; MMP9 ; Type V collagenase
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, extracellular
Chromosome Location
20q13.12
Clonality
Monoclonal
Description
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.
Host
Rabbit
Immunogen
Recombinant full-length human MMP-9 protein
Isotype
IgG
Positive Control
Human spleen tissue or human heart tissue. U937 cells or human PBL whole cell lysate.
Reactivity
Human
Recombinant
TRUE
Regulatory
RUO
Species
Homo Sapiens (Human)
Swissprot
P14780
Gene Id
4318
Clone No
MMP9, 2025R
Symbol
MMP9
Weight
92kDa
Buffer
200μg/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Applications
FACS, IF, IHC-F
Description
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
Flow Cytometry
0.5-1μg/million cells
Immunofluorescence
0.5-1μg/ml
Immunohistology (Formalin-fixed)
0.5-1μg/ml for 30 minutes at RT
No Description Available.
No Description Available.
Reviews of Anti-undefined Antibody MMP9,2025R Unconjugated BHA10208250