CD279 ; hPD-1 ; hSLE1 ; PD1 ; PDCD1 ; Programmed Cell Death Protein 1 ; Protein PD-1 ; SLEB2 ; Systemic lupus erythematosus susceptibility 2
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic, Cell Surface
Chromosome Location
2q37.3
Clonality
Monoclonal
Description
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
Host
Rabbit
Immunogen
Human full-length recombinant PDCD1 protein
Isotype
IgG
Positive Control
TY cells or Tonsil.
Reactivity
Human
Recombinant
TRUE
Regulatory
RUO
Swissprot
Q15116
Gene Id
5133
Clone No
PDCD1, 1410R
Symbol
PDCD1
Weight
55kDa
Buffer
200μg/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Applications
FACS, IF, IHC-F
Description
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
Flow Cytometry
0.5-1μg/million cells
Immunofluorescence
1-2μg/ml
Immunohistology (Formalin-fixed)
1-2μg/ml for 30 minutes at RT
No Description Available.
No Description Available.
Reviews of Anti-undefined Antibody PDCD1,1410R Unconjugated BHA10208281