Anti-undefined Antibody 4C6,4 Unconjugated BHA10208268

Mfr.No.	1029-MSM1-P1ABX
Alternative Names	ARF ; CDK4 inhibitor p16 INK4 ; CDK4I ; CDKN2 ; CDKN2A ; Cell cycle negative regulator beta ; CMM2 ; Cyclin dependent kinase 4 inhibitor A ; Cyclin dependent kinase inhibitor 2A ; INK4 ; INK4a ; Melanoma p16 inhibits CDK4 ; MLM ; MTS 1 ; MTS1 ; Multiple tumor suppressor 1 ; p14 ; p16 ; p16 INK4a ; p16INK4a ; p19 ; P19ARF ; TP16
Antigen	p14ARF
Categories	Primary Antibodies
Cellular Localization	Nuclear, Cytoplasmic
Chromosome Location	9p21.3.
Clonality	Monoclonal
Conjugate	Unconjugated
Description	The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks). Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Multiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1/ p16INK4a) via translation of alternate reading frames, resulting in the pro- duction of the p19 ARF protein in mice and the p14 ARF protein in humans. p14 ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2/M. p14 ARF is negatively regulated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4/cyclin D complex.
Host	Mouse
Immunogen	Recombinant full-length human p14 ARF protein
Isotype	IgG2a
Positive Control	MCF7, H1299 and HeLa cells; human prostate carcinoma.
Reactivity	Human, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P42771
Gene Id	1029
Clone No	4C6, 4
Symbol	ARF
Weight	14kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

FACS, IF, WB, IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

Flow Cytometry	0.5-1μg/million cells
Immunofluorescence	1-2μg/ml
Western Blotting	1-2μg/ml
Immunohistology (Formalin-fixed)	1-2μg/ml for 30 min at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10208268	1029-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-undefined Antibody 4C6,4 Unconjugated BHA10208268

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