Anti-undefined Antibody CDH1,2208R Unconjugated BHA10208199

Mfr.No.	999-RBM8-P1ABX
Alternative Names	Arc 1 ; cadherin 1 type 1 E-cadherin ; Cadherin1 ; CAM 120/80 ; CD324 ; CDH1 ; CDHE ; E-Cad/CTF3 ; E-cadherin ; ECAD ; Epithelial cadherin ; epithelial calcium dependent adhesion protein ; Liver cell adhesion molecule (LCAM) ; Uvomorulin (UVO)
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	16q22.1
Clonality	Monoclonal
Description	Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- andP-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as ?-catenin, to regulate cadherin function.E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Host	Rabbit
Immunogen	Recombinant full-length human E-Cadherin protein
Isotype	IgG
Positive Control	LS174T, Raji, HT29, SK-BR3 cells.Prostateor Colon carcinomas.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P12830
Gene Id	999
Clone No	CDH1, 2208R
Symbol	CDH1
Weight	120-80kDa (Mature); 135kDa (Precursor)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

FACS, IF, WB, IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

Flow Cytometry	0.5-1μg/million cells
Immunofluorescence	0.5-1μg/ml
Western Blotting	0.5-1μg/ml
Immunohistology (Formalin-fixed)	1-2μg/ml for 30 minutes at RT

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10208199	999-RBM8-P1ABX	100µg	$393.20		Add to Cart

Anti-undefined Antibody CDH1,2208R Unconjugated BHA10208199

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