This antibody is specific for the soluble form of CD40. It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
Host
Mouse
Immunogen
Ovalbumin-conjugated synthetic peptide (RDPVCHPLGA) from the C-terminal of human CD40
Isotype
IgG1 Kappa
Positive Control
L-428 Cells. Tonsil, Spleen or Thymus
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Species
Homo Sapiens (Human)
Swissprot
P25942
Gene Id
958
Clone No
T8P2G4*A6
Symbol
CD40
Weight
43kDa
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Applications
IF, FACS
Description
Optimal dilution for a specific application should be determined., IF ; FACS
Dilution
Immunofluorescence
1-2μg/ml
Flow Cytometry
0.5-1μg/million cells
Reviews of Anti-undefined Antibody T8P2G4*A6 Unconjugated BHA10208125