Anti-undefined Antibody BCL2,1878R Unconjugated BHA10208076

Mfr.No.	596-RBM8-P1ABX
Alternative Names	Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2
Categories	Primary Antibodies
Cellular Localization	Nuclear membrane, endoplasmic reticulum, Outer mitochondrial membranes
Chromosome Location	18q21.33
Clonality	Monoclonal
Description	This antibody recognizes a protein of 25-26kDa, identified as the bcl-2?lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression ofbcl-2?lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2?lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Host	Rabbit
Immunogen	Recombinant full-length human bcl-2 protein
Isotype	IgG
Positive Control	Jurkat, K562, HL-60, or HeLa Cells. Tonsil or follicular lymphomas.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P10415
Gene Id	596
Clone No	BCL2, 1878R
Symbol	BCL2
Weight	25-26kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

FACS, IF, WB, IHC-F

Description

Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 1mM EDTA Buffer, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

Flow Cytometry	0.5-1μg/million cells
Immunofluorescence	1-2μg/ml
Western Blotting	0.5-1μg/ml
Immunohistology (Formalin-fixed)	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10208076	596-RBM8-P1ABX	100µg	$393.20		Add to Cart

Anti-undefined Antibody BCL2,1878R Unconjugated BHA10208076

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