Anti-undefined Antibody DG1,1487R Unconjugated BHA10207938

Mfr.No.	55107-RBM7-P0
Alternative Names	Anoctamin 1 ; Calcium Activated Chloride Channel ; Discovered On Gastrointestinal Stromal Tumors Protein 1 ; TAOS2 ; ORAOV2 ; TMEM16A
Antigen	DOG-1 / TMEM16A
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Cell Surface
Chromosome Location	11q13.3
Clonality	Monoclonal
Conjugate	Unconjugated
Description	Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.
Host	Rabbit
Immunogen	Recombinant full-length human DOG-1 protein
Isotype	IgG
Positive Control	Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q5XXA6
Gene Id	55107
Clone No	DG1, 1487R
Symbol	TMEM16A
Weight	~114kDa

Buffer	200μg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200μg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

FACS, IF, IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution