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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CDw17 (Lactosylceramide or LacCer) Antibody BHA10207422

SKU : BHA10207422

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NeoBiotechnologies, Inc.

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Mfr.No.	MSM2-1092-P1ABX
Alternative Names	Lactosylceramide ; LacCer ; �-D-galactosyl-(1-4)-�-D-glucosyl-(1-1')-ceramide ; CDw17
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Clonality	Monoclonal
Description	CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor Ī � (TNFĪ �)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
Host	Mouse
Immunogen	β-2 Microglobulin associated proteins from a detergent lysate of human PBL
Positive Control	Human PBL. Tonsil
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Not Known
Uniprot	Not Known
Gene Id	Not Known

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10207422	MSM2-1092-P1ABX	100µg	$393.20		Add to Cart

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