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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD74 Antibody BHA10206867

SKU : BHA10206867

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NeoBiotechnologies, Inc.

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Mfr.No.	972-MSM4-P1ABX
Alternative Names	CLIP ; DHLAG ; Gamma chain of class II antigens ; HLA class II histocompatibility antigen gamma chain ; HLA-DR antigens-associated invariant chain ; HLADR-gamma (HLADG) ; Ia antigen-associated invariant chain ; la-gamma ; Major histocompatibility complex class II invariant chain ; MHC HLA-DR gamma chain
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Paranuclear globular
Chromosome Location	5q33.1
Clonality	Monoclonal
Description	Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Host	Mouse
Immunogen	Recombinant full-length human CD74 protein
Positive Control	Daudi Cells. Tonsil or lymph node.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P044233
Uniprot	436568
Gene Id	972

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; WB

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
WB	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10206867	972-MSM4-P1ABX	100µg	$393.20		Add to Cart

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