Anti-TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody BHA10206592

Mfr.No.	9476-RBP1-P1ABX
Alternative Names	HSMRK222 ; K222TA2 ; Protein MIG-5 ; SFD ; Sorsby fundus dystrophy pseudo-inflammatory ; TIMP metallopeptidase inhibitor 3 ; Tissue Inhibitor of Metalloproteinase 3
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	22q12.3
Clonality	Polyclonal
Description	TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Host	Rabbit
Immunogen	The amino acid sequence (aa175-211), used as the immunogen for TIMP3 Ab, is 100% homologous in human, cow, dog and horse, and 94% homologous in mouse and rat.
Positive Control	Placenta or breast carcinoma
Reactivity	Human, Mouse, Rat, Horse, Cow, Dog
Recombinant	FALSE
Regulatory	RUO

Swissprot	P35625
Uniprot	644633; 714168
Gene Id	7078

Buffer	200μg/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10206592	9476-RBP1-P1ABX	100µg	$393.20		Add to Cart

Anti-TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody BHA10206592

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