AIK2 ; AIM-1 ; ARK-2 ; AurB ; AURKB ; Aurora-1 ; Aurora and Ipl1 like midbody associated protein 1 ; Aurora kinase B ; Aurora-B ; Aurora-related kinase 2
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic, Nuclear
Chromosome Location
17p13.1
Clonality
Monoclonal
Description
Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
Host
Mouse
Immunogen
Recombinant human Aurora B protein fragment (aa89-251) (exact sequence is proprietary)
Positive Control
HeLa cells. Tonsil, Placenta, Hodgkin s Lymphoma or Colon Carcinoma
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
Q96GD4
Uniprot
442658
Gene Id
9212
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB