The mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin (Workshop IV; Code T015). It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.
Host
Mouse
Immunogen
Stimulated human leukocytes
Positive Control
MOLT4 cells. Human thymus.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P29016
Uniprot
1310
Gene Id
910
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, Func
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; Func
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
0.5-1μg/ml
Func
Order Ab without BSA & Azide
Reviews of Anti-CD1b (T-Cell Surface Glycoprotein) Antibody BHA10206068