Anti-MAML2 (Mastermind Like Transcriptional Coactivator 2) Antibody BHA10205959

Mfr.No.	84441-MSM1-P1ABX
Alternative Names	Mam-2 ; MAML2 ; Mastermind-like protein 2
Antigen	MAML2 (Mastermind Like Transcriptional Coactivator 2)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	11q21
Clonality	Monoclonal
Conjugate	Unconjugated
Description	MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.
Host	Mouse
Immunogen	Recombinant human full-length MAML2
Positive Control	MCF-7 cells. Pancreas or Placenta. Bladder or Colon Carcinoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q8IZL2 (Human)
Uniprot	428214 (Human)
Gene Id	84441 (Human)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution