Amplified in squamous cell carcinoma (AIS) ; Chronic ulcerative stomatitis protein (CUSP) ; EEC3 ; Keratinocyte transcription factor KET ; LMS ; NBP ; p40 ; P51/P63 ; p53 like transcription factor ; p53-related protein p63
Categories
Primary Antibodies
Cellular Localization
Nuclear
Chromosome Location
3q28
Clonality
Monoclonal
Description
p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
Host
Mouse
Immunogen
Recombinant human p63 protein fragment (aa3-106) (exact sequence is proprietary)
Positive Control
HEK293 cells or Prostate Carcinoma or Lung or bladder squamous cell carcinoma
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
Q9H3D4
Uniprot
137569
Gene Id
8626
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB